High risk (>50-fold increase in risk)

• Persistently changing mole
• Clinically atypical moles in patient with two family members with melanoma
• Adulthood (vs. childhood)
• >50 nevi ≥2 mm in diameter

Intermediate risk (~10-fold increase in risk)

• Family history of melanoma
• Sporadic clinically atypical moles
• Congenital nevi (?)
• White ethnicity (vs. black or East Asian ethnicity)
• Personal history of prior melanoma

Low risk (2- to 4-fold increase in risk)

• Immunosuppression
• Sun sensitivity or excess exposure to sun

---

Source: Adapted from AR Rhodes et al: JAMA 258:3146, 1987.